We asked Mark Titus for five predictions before Thursday's March Madness games. Here's what he had to say about tonight's matchups …

A 1-seed will lose
I've already explained why I like the Wisconsin Buzzcuts to beat Syracuse tonight, but Michigan State should also be on upset alert. I like Louisville’s chances against the Spartans, if for no other reason than the Cardinals get after it on defense. As has been the case all year, the big concern with Louisville will be its ability to score — especially since Michigan State plays great defense themselves — which is why I think Syracuse is more likely to lose than Michigan State. But if Louisville’s pressure can keep the Spartans offense in check and create some easy baskets off turnovers, if Russ Smith and Kyle Kuric have their jumpers working, and if Peyton Siva continues to play within himself and control the offense, Louisville should be able to put up enough points to pull off the upset.